DRUG DISCOVERY SERVICES

Our team has proficiency in designing new synthetic routes for novel chemistry, rapidly producing literature routes when available. Regularly handling complex, multi-step synthetic routes, our scientists have extensive experience in custom organic synthesis for drug discovery.

With experience in a range of projects, including oncology, diabetes, cardiovascular disease and CNS, our dedicated team can help kick-start your drug discovery program.

Our extensive collection of building blocks is maintained in house, with compound synthesis on a milligram to a multigram scale. We adhere to industry standards, providing final submitted compounds with at least 95% purity or higher.

With multiple drug candidates developed in collaboration with our clients, you can count on our expertise. We offer the following drug discovery services:

Hit Identification and Confirmation

• Quickly and effectively re-synthesize hits from bibliographic data, early screening, or in-silico hit identification.

• Use reported synthetic routes or design new synthetic routes to confirm biological activity of selected hits.

Hit to Lead Generation

• Rapidly generate libraries of compounds with structural diversity from an extensive collection of building blocks.

• Collection of building blocks hand-picked to ensure drug-like properties for bio-active molecules.

Lead Optimization

• Use SAR results analysis to design potential drug molecules with complex and constrained structures to access unexplored areas of molecular structures.

• Advanced lead optimization through individual target molecule synthesis.

• Create advantages for potential patents across a diverse range of industries.

Medicinal Chemistry Expertise

• Use SAR results analysis to design potential drug molecules with complex and constrained structures to access unexplored areas of molecular structures.

• Create advantages to patent potential drugs.

Scale-Up Synthesis

• Run intermediate scale-up synthesis of key intermediates of lead compounds.

• Non-GMP pre-clinical studies up to 500-gram scale.

Technical Transfer

• Optimize R&D synthetic routes into successful process routes for technical transfer to CMO for non-GMP and GMP process manufacturing.

• Reduce amount of reagents and solvents used, replacing carcinogenic or high-boiling point solvents where possible.

• Find alternative purification methods to silica gel chromatography, such as crystallization, selective precipitation/solubility, and acid-base work-up.

• Openly communicate with our team during the process to ensure best transfer of technical information and knowledge.

Patent Application Dossier Writing

With a variety of patents under our team’s belt, our chemists are knowledgeable and experienced in patent writing, we can assist you in beginning the patent application process.